US 11,744,834 B2Granted

Metal-porphyrin complexes for the inactivation of the biological activity of opioids

AssigneeThe Government of the United States of America, as represented by the Secretary of the Navy

InventorsOkhil Nag, Gregory Ellis, Scott Walper, Jeffrey R. Deschamps, D. Andrew Knight, James B. Delehanty

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Abstract

A rhodium-loaded porphyrin complex, comprising the porphyrin (meso-tri(4-sulfonatophenyl) mono(4-carboxyphenyl)porphine (C1S3TPP)) with coordinated with rhodium, effectively neutralizes the biological activity of naturally-occurring and synthetic opioids.

Claims2

Dependent claims

A material comprising the porphyrin (meso-tri(4-sulfonatophenyl) mono(4-carboxyphenyl)porphine (C1S3TPP)) coordinated with rhodium, wherein the porphyrin has the following structure

Dependencies are inferred from the claim text.

Facts

Application: 16/837,342Filed 1 Apr 2020 · us provisional application
Priority: 4 Apr 2019
Published: US 2020/0316085 A18 Oct 2020
Granted: 5 Sep 2023
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

A61K 31/555
Heterocyclic compounds: containing heavy metals, e.g. hemin, hematin, melarsoprol
A61K 47/546
Heterocyclic compounds: porphyrines; Porphyrine with an expanded ring system, e.g. texaphyrine
A61K 47/6923
The form being a particulate, a powder, an adsorbate, a bead or a sphere: the form being an inorganic particle, e.g. ceramic particles, silica…
A61K 47/6929
The form being a solid microparticle having no hollow or gas-filled cores: the form being a nanoparticle, e.g. an immuno-nanoparticle

Family

Application62/829,140Us provisional application · filed 4 Apr 2019
US 2020/0316085 A1Pre-grant publication · published 8 Oct 2020
US 11,744,834 B2This patent

From the US filing history. Foreign family members aren’t listed.

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