System for imaging lesions aligning tissue surface

A system comprising (a) an imaging device comprising a fluorescent light filter, wherein the imaging device is configured to image an area of interest comprising a first area and a second area on a surface of an individual, wherein the first area comprises a lesion,

• (b) a fluorescent fiducial configured to be applied onto the area of interest;
• wherein the fluorescent light filter configured to capture a fluorescent image of the area of interest in a fluorescent mode;
• and
• wherein the imaging device is configured to obtain features of the lesion by combining a visible image and the fluorescent image;
• wherein the fluorescent fiducial comprises;
• a base that is not visible in a predetermined emission spectra when exposed to light in a predetermined excitation spectra comprising:
• a fluorescent calibration mark with a predetermined calibration brightness in the predetermined emission spectra when exposed to light in a predetermined excitation light spectrum,
• a fluorescent focus mark with sharply defined borders adapted for use by an autofocus mechanism of an integrated optical system;
• a pair of measurement marks with predetermined spacing;
• a fluorescent alignment mark visible in both visible light and visible in light in the predetermined emission spectra when exposed to light in the predetermined excitation spectra wherein this mark is not circularly symmetric;
• and
• a direction mark adapted to identify at least one anatomical term of location for the individual.