US 11,740,181 B2Granted

Preparation device, diagnostic apparatus, diagnostic kit and diagnostic system

AssigneeBloom Diagnostics AG

InventorsAngelica Kohlmann, Thomas Vincent Küpper

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Abstract

A preparation device for preparing a sample for measurement of a target biomolecule in a probe of a bodily fluid is disclosed that includes a substrate with a capillary network configured to transport the probe of the bodily fluid along the substrate. The substrate may be provided with a fluorescent, reflective or self-luminescent marker adapted to bind with the target biomolecule to emit a reaction radiation when excited by an excitation source. The fluorescent, reflective or self-luminescent marker is adapted, when bound to the target biomolecule and excited by the excitation source, together with the target biomolecule to emit the reaction radiation at an intensity proportional to a quantity of the target biomolecule in the probe of the bodily fluid.

Claims13

Dependent claims

A diagnostic apparatus for the measurement of a quantity of a target biomolecule in a probe of a bodily fluid prepared by a preparation device that is configured to prepare a sample for measurement of the target biomolecule in the probe of the bodily fluid,

the preparation device comprising:
a substrate with a capillary network configured to transport the probe of the bodily fluid along the substrate,
wherein the substrate is provided with a fluorescent, reflective or self-luminescent marker that is configured to bind with the target biomolecule to emit a reaction radiation, such that when the fluorescent, reflective or self-luminescent marker is bound to the target biomolecule together they are configured to emit the reaction radiation at an intensity proportional to the quantity of the target biomolecule in the probe of the bodily fluid, and
the diagnostic apparatus comprising:
a housing having a seat arranged to accommodate the preparation device in a predefined position and orientation;
an excitation source adapted to illuminate the substrate of the preparation device;
an optical assembly adapted to measure power spectral intensity values of a reaction radiation emitted by a product of reaction on the preparation device, wherein the power spectral intensity values are proportional to the quantity of the target biomolecule in the probe of the bodily fluid;
and
an electronic assembly adapted to process and convert the power spectral intensity values measured by the optical assembly to a quantity value of the target biomolecule in the probe of the bodily fluid,
wherein the electronic assembly comprises a data exchange equipment adapted to receive data from the preparation device and to send data to a remote handheld communication device adapted to receive and display the quantity value of the target biomolecule in the probe of the bodily fluid, and
wherein, when the preparation device is arranged in the seat of the housing, the optical assembly is arranged to ensure a first measurement alignment between the excitation source and the substrate of the preparation device illuminated by the excitation source and to ensure a second measurement alignment between the substrate of the preparation device emitting a reaction light and the electronic assembly.

8 more elements

A diagnostic system comprising:

a preparation device having
a substrate with a capillary network configured to transport the probe of the bodily fluid along the substrate,
wherein the substrate is provided with a fluorescent, reflective or self-luminescent marker that is configured to bind with the target biomolecule to emit a reaction radiation, such that when the fluorescent, reflective or self-luminescent marker is bound to the target biomolecule together they are configured to emit the reaction radiation at an intensity proportional to a quantity of the target biomolecule in the probe of the bodily fluid;
a diagnostic apparatus having
a seat arranged to accommodate the preparation device in a predefined position and orientation,
an excitation source adapted to illuminate the substrate of the preparation device,
an optical assembly adapted to measure power spectral intensity values of a reaction radiation emitted by a product of reaction on the preparation device, wherein the power spectral intensity values are proportional to a quantity of the target biomolecule in the probe of the bodily fluid, and
an electronic assembly adapted to process and convert the power spectral intensity values measured by the optical assembly to a quantity value of the target biomolecule in the probe of the bodily fluid,
wherein the electronic assembly comprises a data exchange equipment adapted to receive data from the preparation device and to send data to a remote handheld communication device adapted to receive and display the quantity value of the target biomolecule in the probe of the bodily fluid;
a server;
and
a mobile communication device adapted to communicate with the diagnostic apparatus and the server, wherein the server is arranged to receive data signals from the mobile communication device corresponding to measured quantity values of the target biomolecule in probes of a bodily fluid and to send data signals to the mobile communication device corresponding to an evaluation of the measured quantity values, and
wherein the server comprises a data storage, and the server is adapted
to anonymize data received from the mobile communication device,
to store the anonymized data in the data storage,
to evaluate the stored data with respect to a specific topic, and
to provide results of the evaluation of the stored data.

14 more elements

Dependencies are inferred from the claim text.

Facts

Application: 16/765,269Filed 13 Dec 2018
Priority: CH 01514/1713 Dec 2017
Published: US 2020/0371031 A126 Nov 2020
Granted: 29 Aug 2023
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

G01N 21/6428
Fluorescence; Phosphorescence: measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g.…
G01N 21/8483
Systems specially adapted for particular applications: investigating reagent band
G01N 33/54388
Immunochromatographic test strips: based on lateral flow
G01N 33/74
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing:…