Tymovirus virus and virus-like particles as nanocarriers for imaging and therapeutic agents
AssigneeCase Western Reserve University
InventorsNicole F. Steinmetz, Hema Masarapu, He Hu
Life of this patent
Estimating the term…
Abstract
A method of targeting cancer tissue in a subject includes administering to the subject a plurality of functionalized Tymovirus virus or virus-like particles loaded with or conjugated to an imaging agent, a therapeutic agent or a targeting agent.
Claims28
A method of treating and/or detecting cancer tissue in a subject comprising administering to the subject a therapeutically effective amount of a plurality of functionalized Tymovirus virus or Tymovirus virus-like particles (VLPs) loaded with or conjugated to a cancer-specific targeting agent, wherein the plurality of functionalized Tymovirus virus or VLPs are loaded with one or more of an anticancer agent or an imaging agent to image the cancer tissue, and wherein the anticancer agent or imaging agent are is non-covalently encapsulated within an interior surface of the Tymovirus virus or Tymovirus VLPs.
A method of treating and/or detecting cancer tissue in a subject comprising administering to the subject a therapeutically effective amount of a plurality of functionalized Tymovirus virus or Tymovirus virus-like particles (VLPs) loaded with or conjugated to multiple cancer-specific targeting agents and one or both of an anticancer agent or an imaging agent, wherein the spacing and location of the cancer-specific targeting agents on each Tymovirus virus or VLP is controlled to facilitate delivery, targeting, and/or therapeutic efficacy of the Tymovirus virus or VLP.
Dependencies are inferred from the claim text.