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US 11,739,297 B2Granted
Method of increasing tumor killing activity of macrophages or monocytes comprising chimeric antigen receptor
AssigneeCarisma Therapeutics Inc.
InventorsMichael Klichinsky, Nicholas G. Minutolo, Nicholas R. Anderson
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Abstract
The present disclosure pertains to immune cells comprising chimeric antigen receptors (CARs) and methods of using immune cells comprising CARs.
Claims10
A method of modifying ex vivo a macrophage or monocyte comprising a chimeric antigen receptor (CAR) comprising:
- (a) an extracellular domain,
- (b) a transmembrane domain, and
- (c) an intracellular domain, and
- wherein the method comprises treating the macrophage or monocyte with a CD40 agonist,
- thereby producing a modified macrophage or monocyte which exhibits increased tumor killing ability relative to an unmodified macrophage or monocyte.
2 more elements
Dependencies are inferred from the claim text.