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US 11,739,132 B2Granted
Separation moieties and methods of use thereof
AssigneeWerewolf Therapeutics, Inc.
InventorsWilliam Winston, Luke Evnin, Vinay Bhaskar, Giselle Knudsen, Daniel J. Hicklin, Cynthia Seidel-Dugan, Jose Andres Salmeron Garcia, Heather R. Brodkin
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Abstract
Provided herein are separation moieties that are suitable for use in conjunction with a variety of therapeutic payloads. The separation moieties serve to generate conditionally active macromolecules whereby the macromolecules have reduced or minimal biological activity until the separation moieties are modified under specific conditions.
Claims16
A recombinant pro-protein comprising:
- a. a recombinant polypeptide comprising, a cleavable moiety that is a substrate for a protease, wherein the cleavable moiety comprises the amino acid sequence of SEQ ID NO:
- 198 or a functional variant of SEQ ID NO:
- 198 in which one or two amino acids are substituted in SEQ ID NO:
- 198;
- and
- b. a polypeptide with biological activity.
3 more elements
Dependencies are inferred from the claim text.