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US 11,739,083 B2Granted
Disposable sensor chip with reagent including 2-substituted benzothiazolyl-3-substituted phenyl-5-substituted sulfonated phenyl-2H-tetrazolium salt
AssigneeTerumo Kabushiki Kaisha
InventorHiroya Sato
Life of this patent
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Abstract
A disposable sensor chip for biological component concentration measurement includes: a chip main body defining a cavity through which a body fluid is flowable; and a reagent located in the cavity such that the body fluid flowing through the cavity comes into contact with the reagent. The reagent comprises a 2-substituted benzothiazolyl-3-substituted phenyl-5-substituted sulfonated phenyl-2H-tetrazolium salt.
Claims18
A disposable sensor chip for biological component concentration measurement, comprising:
- a chip main body defining a cavity through which a body fluid is flowable;
- and
- a reagent located in the cavity such that the body fluid flowing through the cavity comes into contact with the reagent;
- wherein the reagent comprises a 2-substituted benzothiazolyl-3-substituted phenyl-5-substituted sulfonated phenyl-2H-tetrazolium salt represented by the following Formula (1):
- wherein in Formula (1), R1 represents any one selected from the group consisting of a hydrogen atom, a hydroxyl group, a methoxy group, and an ethoxy group;
- R2 represents any one selected from the group consisting of a nitro group, —OR4, and a carboxyl group;
- R3 represents a hydrogen atom, a methyl group, or an ethyl group, while at least one is a methyl group or an ethyl group;
- R4 represents a methyl group or an ethyl group;
- m represents the number of sulfo groups (—SO3−) bonded to the phenyl group at the 5-position of the tetrazole skeleton, and is 1 or 2;
- n represents the number of R2 bonded to the phenyl group at the 3-position of the tetrazole skeleton, and is an integer from 0 to 2;
- p represents the number of sulfo groups (—SO3−) bonded to the phenyl group at the 3-position of the tetrazole skeleton, and is 0 or 1;
- n+p is 1 or greater;
- q is 1 or 2;
- when q is 2, the OR3's are disposed adjacently to each other and may be bonded to each other and forma ring;
- and X represents a hydrogen atom or an alkali metal atom.
12 more elements
A kit for biological component concentration measurement, comprising:
- a disposable sensor chip comprising:
- a chip main body defining a cavity through which a body fluid is flowable, and
- a reagent located in the cavity such that the body fluid flowing through the cavity comes into contact with the reagent;
- and
- a measurement apparatus comprising:
- a chip mounting part comprising an insertion port and configured to receive the sensor chip, and
- a photometric measuring unit configured to detect a concentration of the biological component in the body fluid that is in the cavity of the chip main body;
- wherein the reagent comprises a 2-substituted benzothiazolyl-3-substituted phenyl-5-substituted sulfonated phenyl-2H-tetrazolium salt represented by the following Formula (1):
- wherein in Formula (1), R1 represents any one selected from the group consisting of a hydrogen atom, a hydroxyl group, a methoxy group, and an ethoxy group;
- R2 represents any one selected from the group consisting of a nitro group, —OR4, and a carboxyl group;
- R3 represents a hydrogen atom, a methyl group, or an ethyl group, while at least one is a methyl group or an ethyl group;
- R4 represents a methyl group or an ethyl group;
- m represents the number of sulfo groups (—SO3−) bonded to the phenyl group at the 5-position of the tetrazole skeleton, and is 1 or 2;
- n represents the number of R2 bonded to the phenyl group at the 3-position of the tetrazole skeleton, and is an integer from 0 to 2;
- p represents the number of sulfo groups (—SO3−) bonded to the phenyl group at the 3-position of the tetrazole skeleton, and is 0 or 1;
- n+p is 1 or greater;
- q is 1 or 2;
- when q is 2, the OR3's are disposed adjacently to each other and may be bonded to each other and forma ring;
- and X represents a hydrogen atom or an alkali metal atom.
16 more elements
Dependencies are inferred from the claim text.