Method for fluoroalkylation of enamines

A method for a fluoroalkylation of an enamine ENAM by a reaction REAC2, wherein

• ENAM is reacted with a fluoro alkyl halide FAHALIDE in the presence of a base BAS;
• wherein
• FAHALIDE is a compound of formula (FAHALIDE);
• X2-R3-X1 (FAHALIDE)
• R3 is C1-20 alkylene, wherein in the alkylene chain at least one of the hydrogens is substituted by F;
• X1 is Cl, Br or I;
• X2 is C(O)—OC1-4 alkyl, F, Br or H;
• BAS is selected from the group consisting of Na3PO4, Na2HPO4, K3PO4, K2HPO4, Na2CO3, NaHCO3, K2CO3, KHCO3, Cs2CO3, CsHCO3, NaOH, KOH, NaOtBu, KOtBu, and DBU;
• wherein the reaction REAC2 is performed in the absence of a metal catalyst, in the absence of a Pd catalyst;
• wherein the fluoroalkylation of said enamine ENAM by a reaction REAC2 occurs at a carbon atom of said ENAM;
• and
• wherein
• ENAM is a compound of formula (ENAM);
• wherein
• the N atom depicted with (i) is a tertiary, non-aromatic N atom;
• the C atoms depicted with (ii) and (iii) are non-aromatic C atoms;
• wherein the reaction is between about 16 hours and about 96 hours and the reaction temperature is between about 25° C. and about 80° C.;
• and
• wherein the reaction REAC2 excludes perfluoroalkyl iodide.