Method for synthesizing artepillin C and intermediate compound thereof

A method for synthesizing artepillin C, which comprises the following steps:

• a first reaction step:
• in the presence of a base initiator, a compound A shown in formula I and 3,3-dimethylallyl bromide are mixed in a solvent including at least one selected from toluene, dimethylformamide, tetrahydrofuran, and dimethylsulfoxide to lead a first reaction in an ice bath continuously for 72 hrs, and then water is poured into the reaction solution to stop the reaction to generate a first reaction product, which comprises an intermediate of artepillin C shown in formula II,
• in which R is C1-6 alkyl, and
• a second reaction step:
• the intermediate of artepillin C is dissolved in an aqueous alcohol solution and then mixed with an alkali metal salt, and the reaction continues for a second reaction time to generate a second reaction product, which comprises artepillin C shown in formula IV;
• wherein
• in the first reaction step, the molar ratio of the compound A to 3,3-dimethylallyl bromide is 1:2, the molar ratio of the compound A to the base initiator is 1:2, and the first reaction is carried out in a vacuum environment with argon;
• and
• in the second reaction step, the second reaction time is in the range of 8 h to 20 h.