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US 11,738,096 B2Granted
Method of detecting diseased or damaged tissue with a pH-triggered polypeptide fluorophore composition
AssigneesYale University, University of Rhode Island Board of Trustees
InventorsYana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
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Abstract
The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
Claims14
A method for detecting diseased or damaged tissue in a subject, comprising:
- (a) administering a pH-triggered polypeptide fluorophore composition comprising the structure:
- (b) contacting the subject with electromagnetic radiation comprising an excitation wavelength of the fluorophore;
- and
- (c) detecting electromagnetic radiation emitted from the composition, wherein detection of the radiation indicates the presence of the diseased or damaged tissue.
1 more element
Dependencies are inferred from the claim text.