Boryl ethers, carbonates, and cyclic acetals as oxidatively-triggered drug delivery vehicles
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsPaul E. Floreancig, Alexander Deiters, Ramsey D. Hanna, Yuta R. Naro
Life of this patent
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Abstract
A compound, or a pharmaceutically acceptable salt thereof, having a structure of: wherein L is a cleavable linker group; X is a cargo moiety-containing group; and R1 and R2 are each independently hydrogen, alkyl, or substituted alkyl; or R1 and R2 together form a boronic ester ring or a substituted boronic ester group.
Claims27
A compound, or a pharmaceutically acceptable salt thereof, having a structure of:
- wherein L is a cleavable linker group;
- X is a cargo moiety-containing group;
- and
- R1 and R2 are each independently hydrogen, alkyl, or substituted alkyl;
- or R1 and R2 together form a boronic ester ring or a substituted boronic ester group;
- wherein L is:
- wherein R5, R6, and R7 are each independently selected from hydrogen, alkyl, substituted alkyl, thiol or substituted thiol, or a targeting moiety.
A compound, or a pharmaceutically acceptable salt thereof, having a structure of:
- wherein L is a cleavable linker group that includes an —O—, —C(O)—, or —O—C(O)—O—, and L includes a targeting moiety;
- X is a cargo moiety-containing group;
- and
- the —B(OR1)(OR2) group is selected from the following:
A compound, or a pharmaceutically acceptable salt thereof, having a structure of:
- wherein L is a cleavable linker group;
- X is a cargo moiety-containing group;
- and
- the —B(OR1)(OR2) group is selected from the following:
- wherein L is selected from:
- wherein R3-R7 are each independently selected from hydrogen, alkyl, substituted alkyl, thiol or substituted thiol, or a targeting moiety, provided at least one of R3-R7 includes a targeting moiety.
Dependencies are inferred from the claim text.