Back to results
US 11,738,056 B2Granted
Compositions and methods for improving mitochondrial function
AssigneeThe General Hospital Corporation
InventorsGary Ruvkun, J. Amaranath Govindan, Elamparithi Jayamani
Life of this patent
Estimating the term…
Abstract
Provided herein are methods and compositions comprising a bacterium or a metabolite thereof for enhancing mitochondrial and/or peroxisomal function.
Claims17
A method of treating Alzheimer's Disease, the method comprising:
- administering to a subject at risk of or suffering from Alzheimer's Disease, a therapeutically effective amount of a composition, thereby reducing the severity of at least one symptom of Alzheimer's Disease compared to a subject without the administration, and
- wherein the composition comprises:
- a measured amount of a bacterial species that comprises and expresses nucleic acid sequences encoding membrane-bound PQQ-dependent glucose dehydrogenase (mGDH), ubiquinol-cytochrome c reductase iron-sulfur subunit, TonB-dependent receptor, carbon-nitrogen hydrolase, and ubiquinol oxidase subunit II, or an extract or fraction derived therefrom,
- wherein the extract or fraction of the bacterial species comprises membrane-bound PQQ-dependent glucose dehydrogenase (mGDH), ubiquinol-cytochrome c reductase iron-sulfur subunit, TonB-dependent receptor, carbon-nitrogen hydrolase, and ubiquinol oxidase subunit II expressed from the nucleic acid sequences,
- wherein the bacterial species is from the Acetobacteriaceae family.
2 more elements
A method of treating Parkinson's Disease, the method comprising:
- administering to a subject at risk of or suffering from Parkinson's Disease, a therapeutically effective amount of a composition, thereby reducing the severity of at least one symptom of Parkinson's Disease compared to a subject without the administration, and
- wherein the composition comprises:
- a measured amount of a bacterial species that comprises and expresses nucleic acid sequences encoding membrane-bound PQQ-dependent glucose dehydrogenase (mGDH), ubiquinol-cytochrome c reductase iron-sulfur subunit, TonB-dependent receptor, carbon-nitrogen hydrolase, and ubiquinol oxidase subunit II, or an extract or fraction derived therefrom,
- wherein the extract or fraction of the bacterial species comprises membrane-bound PQQ-dependent glucose dehydrogenase (mGDH), ubiquinol-cytochrome c reductase iron-sulfur subunit, TonB-dependent receptor, carbon-nitrogen hydrolase, and ubiquinol oxidase subunit II expressed from the nucleic acid sequences,
- wherein the bacterial species is from the Acetobacteriaceae family.
2 more elements
A method of treating Huntington's Disease, the method comprising:
- administering to a subject at risk of or suffering from Huntington's Disease, a therapeutically effective amount of a composition, thereby reducing the severity of at least one symptom of Huntington's Disease compared to a subject without the administration, and
- wherein the composition comprises:
- a measured amount of a bacterial species that comprises and expresses nucleic acid sequences encoding membrane-bound PQQ-dependent glucose dehydrogenase (mGDH), ubiquinol-cytochrome c reductase iron-sulfur subunit, TonB-dependent receptor, carbon-nitrogen hydrolase, and ubiquinol oxidase subunit II, or an extract or fraction derived therefrom,
- wherein the extract or fraction of the bacterial species comprises membrane-bound PQQ-dependent glucose dehydrogenase (mGDH), ubiquinol-cytochrome c reductase iron-sulfur subunit, TonB-dependent receptor, carbon-nitrogen hydrolase, and ubiquinol oxidase subunit II expressed from the nucleic acid sequences,
- wherein the bacterial species is from the Acetobacteriaceae family.
2 more elements
Dependencies are inferred from the claim text.