Multiplexing method for separators
AssigneeMicromass UK Limited
InventorMartin Raymond Green
Life of this patent
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Abstract
The present disclosure provides a method comprising providing a sample to be analysed, separating successive populations of ions from said sample in a separator, wherein said populations of ions are introduced into said separator at regular intervals, and the intervals are timed such that at least some ions in a subsequent population of ions overlap ions in a preceding population of ions, varying one or more parameters of said separator such that different populations of ions experience different separation conditions, detecting ions from said populations of ions and obtaining a convolved data set, and de¬ convolving said convolved data set using the known variance of the parameters and outputting data corresponding to the successive populations of ions.
Claims16
A method comprising:
- providing a sample to be analysed;
- separating successive populations of ions from said sample in a separator, wherein said populations of ions are introduced into said separator at intervals, and the intervals are timed such that ions in a subsequent population of ions overlap ions in a preceding population of ions, within the separator;
- varying one or more parameters of said separator such that different populations, of said successive populations of ions, experience different separation conditions;
- detecting ions from said populations of ions and obtaining a convolved data set;
- and
- de-convolving said convolved data set using the known variance of the parameters and outputting data corresponding to the successive populations of ions.
An apparatus for separating and analysing ions, the apparatus comprising an ion separator, a detector and a control system, wherein the control system is arranged and adapted to:
- separate successive populations of ions from a sample, and introduce said populations of ions into a separator at intervals, wherein the intervals are timed such that ions in a subsequent population of ions overlap ions in a preceding population of ions, within the separator;
- vary one or more parameters of said separator such that different populations, of said successive populations of ions, experience different separation conditions;
- detect ions from said populations of ions and obtain a convolved data set;
- and
- de-convolve said convolved data set using the known variance of the parameters and outputting data corresponding to the successive populations of ions.
Dependencies are inferred from the claim text.