Compositions and methods for treating COVID-19
AssigneeVast Sea Biotechnology, Inc.
InventorsNorman Zhennan Lai, Yuebin Tan, Ying Wang
Life of this patent
Estimating the term…
Abstract
This disclosure is directed to inhibitory oligonucleotides, inhibitory peptides, compositions and methods for preventing or treating Coronavirus disease 2019 (COVID-19). In one aspect, the disclosure is directed to compositions that comprise inhibitory oligonucleotides against one or more SARS-CoV-2 virus genes. In another aspect, the disclosure is directed to compositions that comprise inhibitory peptides that inhibit SARS-COV-2 entry into cells. Another aspect of the disclosure is directed to gene therapy methods for treating COVID-19, and vectors for carrying out the same. Finally, the disclosure provides nutritional supplements to support human immunity and prevent or inhibit viral infections.
Claims16
A composition comprising
- a plurality of peptides each mimicking a different portion of the ligand binding domain (LBD) of human ACE2 protein, wherein each of the peptides is of a length of 15-31 amino acids and prevents binding of the S-protein of SARS-CoV-2 to the human ACE2 protein;
- wherein the plurality of peptides each comprise an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 42-44, 54, and 68-82;
- and
- a plurality of inhibitory oligonucleotides or a combination of nucleic acid vectors encoding said plurality of inhibitory oligonucleotides, wherein the plurality of inhibitory oligonucleotides targets at least two SARS-CoV-2 genes selected from the group consisting of ORF1ab, RdRp, the S-protein gene, the N-protein gene, and the E protein gene.
Dependencies are inferred from the claim text.