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US 11,732,261 B2Granted
Selective antisense compounds and uses thereof
AssigneeIonis Pharmaceuticals, Inc.
InventorsPunit P. Seth, Michael Oestergaard, Eric E. Swayze
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Abstract
The present invention provides oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.
Claims20
An oligomeric compound comprising a modified oligonucleotide having a modification motif comprising:
- a 5′-region consisting of three linked 5′-region nucleosides, wherein the 5′-region has an ABB motif;
- a 3′-region consisting of four linked 3′-region nucleosides, wherein the 3′-region has a BBAB motif;
- and
- a central region between the 5′-region and the 3′-region consisting of 6-12 linked central region nucleosides, each independently selected from a nucleoside comprising a modified sugar moiety and a nucleoside comprising an unmodified deoxyribosyl sugar moiety, wherein the 5′-most central region nucleoside comprises an unmodified deoxyribosyl sugar moiety and the 3′-most central region nucleoside comprises an unmodified deoxyribosyl sugar moiety;
- wherein each A is a nucleoside comprising a non-bicyclic modified sugar moiety, each B is a bicyclic nucleoside.
2 more elements
Dependencies are inferred from the claim text.