Augmenting moieties for anti-inflammatory compounds
AssigneesLehigh University, Rutgers, The State University of New Jersey
InventorsJeffrey D. Laskin, Diane E. Heck, Carl J. Lacey, Ned D. Heindel, Sherri C. Young
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Abstract
Augmented or synergized anti-inflammatory constructs are disclosed including anti-inflammatory terpenes and/or vanilloids covalently conjugated to one another so that the activity of the conjugate is greater than the sum of its parts. Also disclosed are methods of improving the potency of an anti-inflammatory terpene or vanilloid by linking it to another anti-inflammatory terpene or vanilloid via a carbamate linkage, where the potency of the conjugate is greater than the sum of its parts.
Claims9
An anti-inflammatory conjugate having the structure of:
- Formula 1A terpene-(carbamate)- vanilloid, or
- Formula 1B terpene-(carbamate)- terpene, or
- Formula 1C vanilloid-(carbamate)- vanilloid;
- wherein the terpenes of Formula D3 and the vanilloids of Formula IC are the same or different,
- wherein the terpene is selected from the group consisting of thymol, carvacrol, geraniol, nerol, farnesol, citronellol and linalool,
- wherein said vanilloid is independently selected from the group consisting of zingerone, eugenol, vanillyl alcohol, 3-methoxy-4-acetyloxybenzyl alcohol, paradol and vanillylamine.
Dependencies are inferred from the claim text.