Crystal polymorph of 8-bromo-2-(1-methylpiperidin-4-ylamino)-4-(4-phenoxyphenylamino)pyrido[4,3-d]pyrimidin-5(6H)-one hydrochloride and method for preparing same
AssigneeOscotec Inc.
InventorsJung-Ho Kim, Jang-Sik Choi, Hee Kyu Lee, Song-eun Park, Dong-Sik Jung, Yung-Geun Choi, Jong-Sung Koh, Se-Won Kim, Jaekyoo Lee
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Abstract
An embodiment relates to a crystal polymorph of 8-bromo-2-(1-methylpiperidin-4-ylamino)-4-(4-phenoxyphenylamino)pyrido [4,3-d]pyrimidin-5(6H)-one hydrochloride which can effectively suppress FLT3 and has excellent stability even in a high temperature and humid environment, and a method for preparing same.
Claims2
A crystalline form of 8-bromo-2-(1-methylpiperidin-4-ylamino)-4-(4-phenoxyphenylamino)pyrido[4,3-d]pyrimidin-5(6H)-one hydrochloride, which has peaks at diffraction angles (2θ±0.2°) of 5.7°, 8.3°, 8.9°, 15.4°, 16.3°, 17.8°, 18.7°, 21.2°, 22.1°, 24.3°, 25.4°, 26.3°, 28.4°, and 30.8° in the X-ray powder diffraction spectrum using Cu-Kα radiation.
Dependencies are inferred from the claim text.