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US 11,731,928 B2Granted
Co-crystals of sodium benzoate and uses thereof
AssigneeSyneuRx International (Taiwan) Corp.
InventorsGuochuan Emil Tsai, Ching-Cheng Wang, Tien-Lan Hsieh, Yuan-Chun Lo
Life of this patent
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Abstract
Provided are co-crystals of a sodium benzoate compound and a co-former compound of Formula (I) Also provided herein are methods of preparing the co-crystals and uses thereof in treating and/or reducing the risk for a neuropsychiatric disorder (e.g., schizophrenia, psychotic disorders, depressive disorders, or Alzheimer's disease) or a glucose or lipid metabolic disorder (e.g., obesity, diabetes, hypercholesterolemia, hypertension, or hyperlipidemia).
Claims15
A method for treating a disease in a subject, the method comprising:
- administering to a subject in need thereof an effective amount of a co-crystal of sodium benzoate and a co-former, wherein the co-former is a compound of Formula (I):
- in which
- L is alkyl, carbocyclyl, C═C, C═C—C═C, C═C, or absent;
- A is alkyl, carbocyclyl, aryl, or heteroaryl;
- and
- X is O or N—B, B being H, or alkyl;
- provided that when L is absent, A is heteroaryl, and X is O;
- wherein each of the alkyl, carbocyclyl, aryl, and heteroaryl independently is optionally substituted with aralkyl, C1-10 alkyl, halogen, —NH2, or —OH;
- and
- wherein the disease is a neuropsychiatric disorder, which is selected from the group consisting of schizophrenia, depression, anxiety, Huntington's disease, Parkinson's disease, Alzheimer's disease, mild cognitive impairment, and dementia.
7 more elements
Dependencies are inferred from the claim text.