Treatment of depression in certain patient populations
AssigneeAntecip Bioventures II LLC
InventorHerriot Tabuteau
Life of this patent
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Abstract
This disclosure relates to administration of a combination of: 1) about 100-110 mg, about 104-106 mg, or about 105 mg of bupropion hydrochloride, or a molar equivalent amount of a free base form or another salt form of bupropion; and 2) about 40-50 mg, about 44-46 mg, or about 45 mg of dextromethorphan hydrobromide, or a molar equivalent amount of a free base form or another salt form of dextromethorphan in certain patient populations, such as patients having moderate renal impairment, patients receiving a concomitant strong CYP2D6 inhibitor, patients who are known CYP2D6 poor metabolizers, those in need of an NMDA antagonist that does not cause dissociation, and those at risk of QT prologation.
Claims20
A method of treating major depressive disorder in a human patient who has moderate renal impairment, comprising administering once daily, by mouth, one tablet containing about 105 mg of bupropion hydrochloride and about 45 mg of dextromethorphan hydrobromide to the human patient who has moderate renal impairment and is experiencing major depressive disorder, wherein the dextromethorphan hydrobromide is in an immediate-release formulation, wherein the bupropion hydrochloride is in an extended-release formulation, and wherein the tablet is a bilayer tablet.
A method of treating major depressive disorder in a human patient who has moderate renal impairment, comprising administering once daily, by mouth, one tablet containing about 105 mg of bupropion hydrochloride and about 45 mg of dextromethorphan hydrobromide to the human patient who has moderate renal impairment and is experiencing major depressive disorder, wherein the dextromethorphan hydrobromide is in an immediate-release formulation, wherein the bupropion hydrochloride is in an extended-release formulation, and wherein the Tmax of dextromethorphan is about 3 hours.
A method of treating major depressive disorder in a human patient who has moderate renal impairment, comprising administering a daily dose of:
- (i) about 105 mg of bupropion hydrochloride and (ii) about 45 mg of dextromethorphan hydrobromide to the human patient who has moderate renal impairment and is experiencing major depressive disorder, and wherein the human patient has an estimated glomerular filtration rate that is between about 30 mL/min/1.72 m2 and 59 mL/min/1.72 m2.
Dependencies are inferred from the claim text.