Syringe assembly with ion-exchange material
AssigneeSwedish Orphan Biovitrum AB (publ)
InventorJonas Fransson
Life of this patent
Estimating the term…
Abstract
A pre-filled syringe is disclosed, comprising a barrel and a plunger, the barrel having an outlet, the barrel containing a pharmaceutically acceptable solution having a non-physiological pH, wherein the syringe further comprises an ion exchange material. The ion exchange material is provided at a position to allow contact with the pharmaceutically acceptable solution upon ejection of the pharmaceutically acceptable solution from the barrel via the outlet. The ion exchange material is capable of adjusting the pH of the solution from a non-physiological pH, at which the pharmaceutically acceptable solution is stored in order to ensure acceptable shelf life, to a more physiological pH at which the discomfort and/or pain experienced during injection may be alleviated.
Claims15
A syringe comprising a barrel and a plunger, the barrel having an interior volume adapted to contain a liquid pharmaceutical composition having a first, non-physiological pH, wherein the syringe further comprises an ion exchange material provided within the syringe such that it is not in fluid communication with the interior volume of the barrel, and wherein the ion exchange material is provided at a position to, in use, allow contact with the liquid pharmaceutical composition upon ejection of the liquid pharmaceutical composition from the barrel, wherein the ion exchange material is insoluble and/or immiscible in the liquid pharmaceutical composition and is adapted to, upon contact with the liquid pharmaceutical composition, adjust the pH of the liquid pharmaceutical composition from the first, non-physiological pH to a second pH, wherein the first, non-physiological pH is in the range of 3-6.6 and the second pH is in the range of 7.0-8.0, wherein the second pH is higher than the first non-physiological pH.
A pre-filled syringe comprising a barrel and a plunger, the barrel having an outlet, the barrel containing a liquid pharmaceutical composition having a first, non-physiological pH, wherein the syringe further comprises an ion exchange material provided such that the liquid pharmaceutical composition, when contained within the barrel, does not contact the ion exchange material, and wherein the ion exchange material is provided at a position to allow contact with the liquid pharmaceutical composition upon ejection of the liquid pharmaceutical composition from the barrel via the outlet, wherein the ion exchange material is insoluble and/or immiscible in the liquid pharmaceutical composition and is adapted to, upon contact with the liquid pharmaceutical composition, adjust the pH of the liquid pharmaceutical composition from the first, non-physiological pH to a second pH, wherein the first, non-physiological pH is in the range of 3-6.6 and the second pH is in the range of 7.0-8.0, wherein the second pH is higher than the first non-physiological pH.
Dependencies are inferred from the claim text.