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US 11,730,407 B2Granted
Polymer membranes for continuous analyte sensors
AssigneeDexCom, Inc.
InventorsRobert Boock, Monica Rixman Swinney, Huashi Zhang, Michael J. Estes, Kristina Lawrence
Life of this patent
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Abstract
Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
Claims17
A sensor for measurement of an analyte, the sensor comprising:
- an in vivo portion configured to be inserted within a body of a host, the in vivo portion comprising:
- an electrode configured to measure a signal associated with an analyte concentration in the host;
- and
- a membrane located over at least a portion of the electrode, wherein the membrane comprises an enzyme;
- and
- an ex vivo portion configured to remain outside of the body of the host,
- wherein the sensor is configured to be calibrated based on a correlation between an in vivo sensor sensitivity and an in vitro sensor sensitivity;
- wherein the sensor is configured to provide, at analyte concentrations of from 40 mg/dL to 400 mg/dL, a level of accuracy corresponding to a mean absolute relative difference of between 7% to 10% over a sensor session of anywhere between 1 to 30 days, and
- wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood.
6 more elements
A sensor for measurement of an analyte, the sensor comprising:
- an in vivo portion configured to be inserted within a body of a host, the in vivo portion comprising:
- an electrode configured to measure a signal associated with an analyte concentration in the host and
- a membrane located over at least a portion of the electrode, wherein the membrane comprises an enzyme;
- and
- an ex vivo portion configured to remain outside of the body of the host,
- wherein the sensor is configured to be calibrated based on a correlation between an in vivo sensor sensitivity and an in vitro sensor sensitivity;
- wherein the sensor is configured to provide, at analyte concentrations of from 40 mg/dL to 400 mg/dL, a level of accuracy corresponding to a mean absolute relative difference of between 5% to 15% over a sensor session of anywhere between 1 to 30 days, and
- wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood
- wherein the sensor is configured to provide, at analyte concentrations of from 40 mg/dL to 80 mg/dL, a second level of accuracy corresponding to a second mean absolute relative difference, the mean absolute relative difference being less than the second mean absolute relative difference.
6 more elements
A sensor for measurement of an analyte, the sensor comprising:
- an electrode configured to measure a signal associated with an analyte concentration in a host;
- an enzyme domain;
- and
- a membrane in contact with the enzyme domain, wherein the membrane is located over at least a portion of the electrode, and wherein the membrane configured to reduce a flux of one or more interferents from reaching the enzyme domain,
- wherein the sensor is configured to provide, at analyte concentrations of from 40 mg/dL to 400 mg/dL, a level of accuracy corresponding to a mean absolute relative difference of between 7% to 10% over a sensor session of between 1 to 30 days, and
- wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood.
3 more elements
A sensor for measurement of an analyte, the sensor comprising:
- an electrode configured to measure a signal associated with an analyte concentration in a host
- an enzyme domain;
- and
- a membrane in contact with the enzyme domain, wherein the membrane is located over at least a portion of the electrode, and wherein the membrane configured to reduce a flux of one or more interferents from reaching the enzyme domain,
- wherein the sensor is configured to provide, at analyte concentrations of from 40 mg/dL to 400 mg/dL, a level of accuracy corresponding to a mean absolute relative difference of between 5% to 15% over a sensor session of between 1 to 30 days, and
- wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood
- wherein the sensor is configured to provide, at analyte concentrations of from 40 mg/dL to 80 mg/dL, a second level of accuracy corresponding to a second mean absolute relative difference, the mean absolute relative difference being less than the second mean absolute relative difference.
4 more elements
Dependencies are inferred from the claim text.