Back to results
US 11,726,096 B2Granted
Fast protein sequencing
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsYuan Mao, Qiangwei Xia, Lichao Zhang
Life of this patent
Estimating the term…
Abstract
Methods of sequencing a protein using a novel digestion-on-emitter technology are provided.
Claims28
A method of analyzing at least one protein in a sample, said method comprising:
- mixing a protease enzyme with said sample to form a final sample;
- contacting the final sample to an electrospray emitter;
- and
- analyzing the final sample using a tandem mass spectrometry, wherein digestion of the at least one protein by the protease enzyme occurs on the electrospray emitter and wherein the digestion is monitored in real time.
1 more element
A method of sequencing at least one protein in a sample, said method comprising:
- mixing a protease enzyme with said sample to form a final sample;
- contacting the final sample to an electrospray emitter;
- and
- analyzing the final sample using a tandem mass spectrometry, wherein digestion of the at least one protein by the protease enzyme occurs on the electrospray emitter and wherein the digestion is monitored in real time.
1 more element
A method of characterizing at least one protein in a sample, said method comprising:
- mixing a protease enzyme with said sample to form a final sample;
- contacting the final sample to an electrospray emitter;
- and
- analyzing the final sample using a tandem mass spectrometry, wherein digestion of the at least one protein by the protease enzyme occurs on the electrospray emitter and wherein the digestion is monitored in real time.
1 more element
Dependencies are inferred from the claim text.