CXCL10 binding proteins and compositions thereof

An isolated C-X-C motif chemokine ligand 10 (CXCL10) binding protein, wherein the binding protein comprises a variable region of an immunoglobulin or an antigen-binding domain of an antibody and binds to full-length human CXCL10 with a KD of 50 nM or less, but does not bind N-terminally truncated CXCL10 and, wherein the binding protein requires the N-terminal valine and/or proline of the epitope NH2-VPLSRTVRCTCISISNQPVNPRSLE-COOH) (SEQ ID NO:

• 25) to bind to full-length human CXCL10, wherein the binding protein is an antibody or antigen-binding fragment thereof comprising:
• (A)(i) a heavy chain variable region (VH) comprising:
• a) a complementarity determining region (CDR) 1 comprising a sequence set forth in amino acids 25-34 of SEQ ID NO:
• 3;
• b) a CDR2 comprising a sequence set forth in amino acids 49-65 of SEQ ID NO:
• 3;
• and
• c) a CDR3 comprising a sequence set forth in amino acids 98-108 of SEQ ID NO:
• 3;
• and
• (ii) a light chain variable region (VL) comprising:
• a) a CDR1 comprising a sequence set forth in amino acids 23-33 of SEQ ID NO:
• 4;
• b) a CDR2 comprising a sequence set forth in amino acids 49-55 of SEQ ID NO:
• 4;
• and
• c) a CDR3 comprising a sequence set forth in amino acids 88-96 of SEQ ID NO:
• 4;
• or
• (B)(i) a VH comprising:
• a) a CDR1 comprising a sequence set forth in SEQ ID NO:
• 5;
• b) a CDR2 comprising a sequence set forth in SEQ ID NO:
• 6;
• and
• c) a CDR3 comprising a sequence set forth in SEQ ID NO:
• 7;
• and
• (ii) a VL comprising:
• a) a CDR1 comprising a sequence set forth in SEQ ID NO:
• 8;
• b) a CDR2 comprising a sequence set forth in SEQ ID NO:
• 9;
• and
• c) a CDR3 comprising a sequence set forth in SEQ ID NO:
• 10.