Conjugates of tumor necrosis factor inhibitors to functionalized polymers

A method of making a TNF inhibitor conjugate, said method comprising reacting a TNF inhibitor with a preparation comprising a compound of formula (3):

• or a salt form thereof, wherein:
• polymer is a linear, water-soluble, non-peptidic, and non-nucleotidic polymer backbone, wherein M2 and the phosphonate-derived functional group are each bonded at a different terminus of said polymer;
• E and E′ are each O;
• K is selected from:
• alkylene, alkyleneoxyalkylene, and oligomeric alkyleneoxyalkylene;
• G is selected from:
• hydrogen, alkoxy, and a hydrophobic separation handle;
• Z1 and Z2 are each O;
• L is selected from:
• a divalent radical of nucleoside, alkylene, alkyleneoxyalkylene, oligomeric alkyleneoxyalkylene, and unsubstituted and substituted arylene;
• M is selected from a protected group that when deprotected is reactive with the TNF inhibitor or a group reactive with the TNF inhibitor;
• M2 is O;
• and
• R is absent, a protecting group, a hydrophobic separation handle, or an activating group;
• R2 is hydrogen or a protecting group;
• wherein when M is a protected group that when deprotected is reactive with the TNF inhibitor, then R is a protecting group or a hydrophobic separation handle;
• and
• wherein when M is a group reactive with a TNF inhibitor, R is absent, hydrogen, or an activating group.