Polypeptides comprising a modified bacteriophage G3P amino acid sequence lacking a glycosylation signal

A polypeptide comprising a variant of a starting amino acid sequence, wherein the polypeptide binds to and/or disaggregates amyloid;

• wherein the starting amino acid sequence is amino acids 1-217 of SEQ ID NO:1:
• wherein the variant at least differs from the starting amino acid sequence by removal of the putative glycosylation signal at amino acids 39-41;
• wherein the variant optionally and additionally differs from the starting amino acids sequence by:
• one or more modifications selected from:
• (i) substitution of VVV at amino acids 43-45 with AAA;
• (ii) substitution C53W;
• (iii) deletion of amino acids 96-103;
• (iv) substitution of QPP at amino acids 212-214 with AGA;
• (v) substitutions W181A, F190A and F194A;
• (vi) deletion of amino acid 1;
• (vii) deletion of amino acids 1 and 2;
• and
• (viii) addition of a N-terminal methionine residue;
• and
• wherein the variant has decreased immunogenicity resulting from substitution of V215A and G220E as compared to SEQ ID NO:1 and from deletion of amino acid corresponding to amino acids 258 and 259 of SEQ ID NO:1.