Methods of improving cell-based therapy
AssigneeThe Regents of the University of California
InventorsNipavan Chiamvimonvat, Bruce D. Hammock, Padmini Sirish
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Abstract
Provided are methods for improving the efficacy and success of cell-based therapies by administration of stem cells which have been preconditioned with an inhibitor of soluble epoxide hydrolase (sEHI), as well as kits, stents and patches for administering sEHI-preconditioned stem cells, as sole active agent or in combination with an agent that increases the production and or levels of EETs.
Claims16
A method of increasing, improving and/or promoting the survival, engraftment, and/or integration of transplanted stem cells in a tissue of a subject in need thereof, comprising:
- a) exposing a population stem cells in vitro to an agent that increases the production and/or level of epoxy fatty acids (EpFA), or mimics thereof, under conditions and for a time sufficient to increase epoxy fatty acids (EpFA) and/or inhibit soluble epoxide hydrolase in the stem cells, thereby producing preconditioned stem cells;
- and
- b) administering to the subject the preconditioned stem cells, wherein the stem cells are selected from multipotent stem cells, pluripotent stem cells, and induced pluripotent stem cells.
Dependencies are inferred from the claim text.