Preservative removal from eye drops
AssigneeTearclear Corp.
InventorsMichael Wilson, Michael Williams, Deniz Hay, Michael Malanga
Life of this patent
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Abstract
A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of oxidized polyolefin (OxPO). The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The OxPO have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.
Claims23
A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug, the particulate plug comprising microparticles of a polymer comprising oxidized polyolefin (OxPO) wherein the microparticles form a particulate plug having a hydraulic permeability greater than 0.01 Da, wherein the particulate plug formed from the microparticles of the polymer comprising the OxPO has a partition coefficient for the preservative that is greater than a partition coefficient for the drug.
A method of removing a preservative from a drug solution, suspension, or emulsion, comprising:
- providing a container having an extended outlet and a chamber for holding the drug solution, suspension, or emulsion comprising at least one drug and a preservative, the container comprising a particulate plug within the extended outlet, wherein the particulate plug comprises microparticles of a polymer comprising oxidized polyolefin (OxPO), and wherein the microparticles form a particulate plug having a hydraulic permeability greater than 0.01 Da;
- and
- forcing the drug solution, suspension, or emulsion through the particulate plug, wherein the particulate plug selectively removes a preservative from the solution, emulsion, or suspension.
Dependencies are inferred from the claim text.