Synthetic promoters
AssigneeMassachusetts Institute of Technology
InventorsTimothy Kuan-Ta Lu, Lior Nissim, Ming-Ru Wu
Life of this patent
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Abstract
Synthetic promoters that are differentially modulated between certain diseased cells (e.g., cancer cells) and normal cells (e.g., non-cancer cells) are described. The synthetic promoters may be used to drive expression of gene(s) of interest in a specific cell type or during a specific cellular state. These synthetic promoters are useful, for example, for targeted expression of therapeutic molecules in diseased cells.
Claims7
An engineered nucleic acid comprising a promoter that comprises the following sequence:
- TFBS-AGA-TFBS-TCG-TFBS-GAC-TFBS-CTA-TFBS-ACT-TFBS-TGC-TFBS-GTA-TFBS, wherein TFBS comprises the following sequence:
- CCACGTGC (SEQ ID NO:
- 12265).
An engineered nucleic acid comprising a promoter that comprises a nucleotide sequence identified by SEQ ID NO:
- 41, or a nucleotide sequence at least 95% identical to a nucleotide sequence identified by SEQ ID NO:
- 41.
Dependencies are inferred from the claim text.