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US 11,718,646 B2Granted
Bovine adrenal medulla peptide 8-22 compounds and methods of use thereof for treating pain
AssigneesTufts Medical Center, Inc., Trustees of Tufts College
InventorsAlan S. Kopin, Krishna Kumar, Jamie Raudensky Doyle
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Abstract
The present disclosure relates to, among other things, compounds and methods for treating neuropathic pain, ocular pain, ocular inflammation, and/or dry eye and methods of detecting mutations in specific G-protein coupled receptors, such as missense mutations, and determining the extent to which these mutations alter the pharmacological response of the G-protein coupled receptor.
Claims11
A composition comprising a bovine adrenal medulla peptide 8-22 (BAMS-22) peptide coupled to a lipid anchor through a synthetic linker, wherein:
- the BAMS-22 peptide comprises the amino acid sequence of SEQ ID NO:
- 1;
- or
- the BAMS-22 peptide comprises an amino acid modification selected from a M to A substitution at position 15 of SEQ ID NO:
- 1 (M15A), and a Y to W substitution at position 17 of SEQ ID NO:
- 1 (Y17W);
- and
- the synthetic linker and the lipid anchor are coupled to the C-terminus of the BAMS-22 peptide.
5 more elements
Dependencies are inferred from the claim text.