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US 11,718,641 B2Granted
Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
AssigneeEnanta Pharmaceuticals, Inc.
InventorsGuoqiang Wang, Yat Sun Or, Ruichao Shen, Jiang Long, Peng Dai, Xuechao Xing, Jing He
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Abstract
The present invention provides compounds of Formula I, pharmaceutical compositions comprising these compounds and methods of using these compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions.
Claims5
A compound represented by Formula (VI-A) or (VI-B), or a pharmaceutically acceptable salt thereof:
- wherein:
- m is 0, 1, 2 or 3;
- and
- R10 is selected from hydrogen, substituted or unsubstituted —C1-C8 alkyl, substituted or unsubstituted —C2-C8 alkenyl, substituted or unsubstituted —C2-C8 alkynyl, and substituted or unsubstituted —C3-C8 cycloalkyl.
1 more element
Dependencies are inferred from the claim text.