Bis-cyclic guanidines as antibacterial agents

A method of preparing a compound of Formula (I)

• wherein
• R1 at each occurrence is independently hydrogen, C1-C10 alkyl, alkenyl, alkynyl, aryl, aryl-C1-C6 alkyl, cycloalkyl, or cycloalkyl-C1-C6 alkyl;
• R2 at each occurrence is independently hydrogen, C1-C10 alkyl, alkenyl, alkynyl, aryl, aryl-C1-C6 alkyl, cycloalkyl, or cycloalkyl-C1-C6 alkyl;
• X is O or NH
• L1 is —(CRxRy)n1;
• L2 is —(CRxRy)n2;
• L is —(CRxRy)n3—(CH2CH2O)m1-G-(CH2CH2O)m2—(CRxRy)n4—
• Rx and Ry at each occurrence is independently hydrogen or C1-C4 alkyl;
• G is a bond or -(G1)t-, wherein G1 at each occurrence is independently aryl, cycloakyl, heteroaryl, or heterocycle;
• n1 and n2 are each independently 1-4;
• m1, m2, n3, and n4 are each independently 0-10;
• t is 1, 2, 3, or 4;
• and
• wherein R1, R2, Rx, Ry, and G1 optionally are each independently substituted with one or more substituents selected from the group consisting of halogen, cyano, —OH, C1-C6 alkoxy, —COOH, C1-C6 alkoxycarbonyl, oxo, and amino;
• comprising:
• reacting an intermediate of Formula (I-i)
• to form the compound of Formula (I).