Cyclodextrin-linked polyvalent ligands for complexation of metal ions
OwnerChang-Chun Ling, Pier-Luc Champagne +2inventors
InventorsChang-Chun Ling, Pier-Luc Champagne, Ping Zhang, Géraldine Gouhier
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Abstract
Compounds are described which include polyvalent ligands linked to a cyclodextrin scaffold which exhibit strong binding affinities for lanthanides and favorable characteristics with respect to altering the relaxation time of coordinated water molecules. The compounds are useful as contrast agents in applications such as magnetic resonance imaging. The polyvalent ligands are also useful in applications requiring chelation of metal ions in other applications such as water treatment, sequestration of metal ions and treatment of diseases or conditions caused by exposure to toxic or radioactive metal ions.
Claims20
A compound of formula Mz(L), wherein:
- M is a metal ion;
- L is a ligand of formula I
- A-[W—X—Y—N(CH2COOH)2]n (formula I);
- and
- z is an integer of 1 to 4,
- wherein, with reference to formula I,
- A is cyclodextrin or a derivative thereof, a disaccharide, starch or other carbohydrate polymer;
- W is a chemical bond, or a linker comprising a substituted or unsubstituted C1-C5 carbon chain;
- X is a five or six membered ring having one or more heteroatoms;
- Y is a linker comprising a substituted or unsubstituted C1-C3 carbon chain;
- and
- n is an integer of 2 to 8.
Dependencies are inferred from the claim text.