Recombinant BCG overexpressing phoP-phoR
AssigneesChengdu Anyong Dingye Biotechnology Co., Ltd., Limited
InventorJun Liu
Life of this patent
Estimating the term…
Abstract
Provided are a live recombinant Mycobacterium bovis-BCG strain and a tuberculosis (TB) vaccine or immunogenic composition comprising a nucleic acid capable of overexpression, the nucleic acid encoding PhoP and PhoR proteins. A method for treatment or prophylaxis of a mammal against challenge by Mycobacterium tuberculosis or Mycobacterium bovis using the strain is also provided.
Claims9
A live recombinant Mycobacterium bovis-BCG strain comprising nucleic acids capable of overexpression and overexpressing both PhoP and PhoR proteins, the recombinant Mycobacterium bovis-BCG strain having improved immunogenicity compared to wild type nonrecombinant Mycobacterium bovis-BCG strain, the recombinant Mycobacterium bovis-BCG strain having virulence comparable with wild type nonrecombinant Mycobacterium bovis-BCG strain, and the recombinant Mycobacterium bovis-BCG strain having a decreased virulence compared to recombinant Mycobacterium bovis-BCG strain overexpressing only PhoP.
Dependencies are inferred from the claim text.