Method for prediction of response to cardiovascular regeneration based on detecting the amount of biomarkers

A method for prediction of response to stem cell therapy for coronary artery disease or ischemic vascular disease, wherein the method comprises

• (i) determining in a sample of a subject the amount of each of the following biomarkers, wherein the biomarkers include each of a growth factor selected from the group consisting of vascular endothelial growth factor (VEGF), Erythropoietin, and FGF, lymphocyte adapter protein, a glycoprotein selected from the group consisting of Vitronectin and granulocyte-colony stimulating factor (GCSF), brain natriuretic peptide (BNP), circulating endothelial progenitor cells (EPC), circulating endothelial cells (CEC), circulating thrombocytes, and circulating mononuclear cells and subpopulations,
• (ii) comparing the total determined amounts of all of the biomarkers in the sample to a baseline value and/or a reference of biomarkers obtained from subjects who had undergone stem cell therapy for coronary artery disease and categorized into responders or nonresponders to the stem cell therapy, and
• (iii) predicting, whether a response to stem cell therapy in the subject is to be expected based on whether the total determined amounts of the biomarkers in the sample are more similar to the baseline value and/or reference of the biomarkers obtained from the responders than that of the nonresponders, or whether a response to stem cell therapy in the subject is not expected based on whether the total determined amounts of the biomarkers in the sample are more similar to the baseline value and/or reference of the biomarkers obtained from the nonresponders than that of the responders.