Process for detecting nucleic acid molecules by magnetic hyperthermia and assembly enabling such detection

An assembly for detecting at least one single-stranded nucleic acid target molecule, the assembly comprising:

• an electromagnet with a gap,
• a micro-channel in which a liquid can flow, the micro-channel comprising at least one part arranged in the gap of the electromagnet, and
• at least one magnetic nanoparticle of the core-shell type having a plurality of single-stranded nucleic acid probe molecules attached thereto, each of the plurality of single-stranded nucleic acid probe molecules being designed to be at least partially hybridized to a single-stranded nucleic acid target molecule by forming a duplex,
• wherein the electromagnet is configured to generate an alternating magnetic field so as to cause magnetic hyperthermia of the magnetic nanoparticle when the magnetic nanoparticle is transported by the liquid into the part of the micro-channel arranged in the gap of the electromagnet and to induce a denaturation of the duplex formed by the single-stranded nucleic acid probe molecule and the single-stranded nucleic acid target molecule.