Microspheres containing decellularized donor tissue and their use in fabricating polymeric structures
AssigneesUniversity of Cincinnati, Children's Hospital Medical Center
InventorsChia-Ying James Lin, Stacey Gruber, Patrick W. Whitlock, Paulomi Ghosh
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Abstract
Decellularized matrix microspheres comprising a polymeric material and a donor tissue are provided. Also disclosed are structures containing a plurality of decellularized matrix microspheres incorporating a first polymer and a donor tissue; and a second polymer, wherein the decellularized matrix microspheres and the second polymer are in the form of a filament. Methods of treating a tissue injury employing the matrix microspheres and structures described as well as their methods of manufacture are also provided.
Claims10
A fabricated filament comprising:
- a plurality of decellularized matrix microspheres comprising a first polymer encapsulating a decellularized donor tissue, wherein the first polymer comprises one or more of polycaprolactone (PCL), polyvinyl acetate (PVAC), ethylene vinyl acetate polymer (EVA), polyvinyl alcohol (PVA), polylactic acid (PLA), polyglycolic acid (PGA), polylactic-co-glycolic acid (PLGA), polyalkyl cyanoacrylate, polyurethane, and nylons;
- and
- a second polymer,
- wherein the decellularized matrix microspheres and the second polymer are co-extruded in the form of the filament.
A method of manufacturing a filament, the method comprising:
- decellularizing a donor tissue;
- encapsulating the donor tissue in a first polymer to provide decellularized matrix microspheres, wherein the first polymer comprises one or more of polycaprolactone (PCL), polyvinyl acetate (PVAC), ethylene vinyl acetate polymer (EVA), polyvinyl alcohol (PVA), polylactic acid (PLA), polyglycolic acid (PGA), polylactic-co-glycolic acid (PLGA), polyalkyl cyanoacrylate, polyurethane, and nylons;
- and
- co-extruding the decellularized matrix microspheres with a second polymer to provide the filament.
Dependencies are inferred from the claim text.