Methods of treating chronic disorders with complement inhibitors

A method of treating a subject in need of treatment for a chronic respiratory disorder or other chronic complement-mediated disorder, the method comprising administering multiple doses of a complement inhibitor to the subject by an intravenous, intramuscular, subcutaneous, or respiratory route according to a dosing schedule in which successive doses are administered on average (i) at least 3 weeks after the plasma concentration of the complement inhibitor decreases to no more than 10% of the maximum plasma concentration that was reached after the previous dose;

• (ii) at intervals such that the subject's complement activation capacity is at least 50% of baseline for on average at least 3 weeks between doses;
• or (iii) at intervals at least equal to 10 times the terminal plasma half-life of the complement inhibitor when administered by the same route;
• and
• wherein the complement inhibitor comprises a protease that degrades C3.