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US 11,712,414 B2Granted
Oral pharmaceutical composition for preventing or treating dry eye syndrome comprising rebamipide or a prodrug thereof
AssigneesSamjin Pharmaceutical Co., Ltd., Astech, Inc.
InventorsEui Hwan Cho, Sung Ju Choi, Sung Woo Lee, Hee Jong Shin, Jong Bae Yoon, Ki Seok Park, Ho Tae Nam
Life of this patent
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Abstract
Disclosed is an oral pharmaceutical composition for preventing or treating dry eye syndrome, which comprises rebamipide or a prodrug thereof, or a pharmaceutically acceptable salt thereof, as an active ingredient. The compounds can treat dry eye syndrome via oral route, and can be thus employed safely and conveniently compared to conventional eye drops.
Claims11
An oral pharmaceutical composition, comprising a pharmaceutically acceptable salt of a prodrug of rebamipide, as an active ingredient,
- wherein the prodrug of rebamipide is 2-morpholinoethyl 2-(4-chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoate represented by Chemical Formulae II, and
- wherein the pharmaceutically acceptable salt is a sulfate of a prodrug of rebamipide, a malonate of a prodrug of rebamipide, or an oxalate of a prodrug of rebamipide:
Dependencies are inferred from the claim text.