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US 11,709,167 B2Granted
Generation of human allergen- and helminth-specific IgE monoclonal antibodies for diagnostic and therapeutic use
AssigneeVanderbilt University
InventorScott A. Smith
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Abstract
The present disclosure is directed to human monoclonal IgE antibodies, and IgG antibodies engineered therefrom. Such engineered antibodies can be used to blunt pathologic IgE responses in subjects, such as in the treatment or prevention of allergies.
Claims8
A pharmaceutical composition comprising:
- a therapeutically effective amount of an antibody or a fragment thereof, wherein the antibody or the fragment thereof binds a peanut Ara h2 allergen, wherein the antibody or antibody fragment comprises heavy chain CDR1 SEQ ID NO:
- 108, heavy chain CDR2 SEQ ID NO:
- 109, heavy chain CDR3 SEQ ID NO:
- 110, light chain CDR1 SEQ ID NO:
- 186, light chain CDR2 SEQ ID NO:
- 187 and light chain CDR3 SEQ ID NO:
- 188;
- and
- a pharmaceutically acceptable carrier.
6 more elements
Dependencies are inferred from the claim text.