Hexose derivatives, preparation and uses thereof
AssigneesFaculdade De Ciencias Da Universidade De Lisboa, Instituto De Tecnologia Química E Biológica António Xavier
InventorsChristopher David Maycock, Maria Rita Mendes Bordalo Ventura Centeno Lima, Eva Correia Lourenço, Maria Helena Dias Dos Santos, Ana Sofia Da Cunha Miguel
Life of this patent
Estimating the term…
Abstract
A compound of formula I: or a salt thereof, wherein: R1 is —OC(H)(X)(CH2)nC(═O)OH; R2 is —OH, —N3, or —N(H)C(═O)CH3; or R1 and R2 together with the carbon atoms to which they are attached form R3 is —H, —CH3, —CH2C(═O)OH, or —CH2OH; X is —H, —CH3, —CH2OH, or CH2C(═O)OH; and n is 0 or 1.
Claims16
A method of stabilizing a polypeptide, comprising adding to a solution containing the polypeptide at least one compound of the following formula (a) or (b) or a salt thereof,
- R1 is —OC(H)(X)(CH2)nC(═O)OH;
- R2 is —OH;
- X is —H, —CH3 or CH2C(═O)OH;
- and
- n is 0 or 1;
- wherein
- R1 is —OC(H)(X)(CH2)nC(═O)OH;
- R2 is —OH;
- X is —H, —CH3, or CH2C(═O)OH;
- and
- n is 0 or 1,
- so as to thereby stabilize the solution of the polypeptide against heat, wherein the stabilization of the polypeptide is measured by an increase in melting temperature of more than 9° C.
Dependencies are inferred from the claim text.