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US 11,708,329 B2Granted
Inhibitors of the WNT/beta-catenin pathway
AssigneeThe Regents of the University of California
InventorsMichael E. Jung, Xiaohong Chen, Cun-Yu Wang, Jiong Li, Jie Zheng
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.
Claims19
A compound having a structure represented by Formula Ib, Ic, Id, IIb, IIc, or IId:
- wherein,
- R4 is C(O)aryl and the aryl in R4 is substituted or unsubstituted;
- and
- R7 is H or alkyl.
1 more element
A compound selected from:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.