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US 11,706,177 B2Granted
RNA targeting methods and compositions
AssigneeThe Salk Institute for Biological Studies
InventorsPatrick D. Hsu, Silvana Konermann
Life of this patent
Estimating the term…
Abstract
Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
Claims30
An isolated protein, comprising:
- (a) at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to SEQ ID NO:
- 212;
- and
- (b) a subcellular localization signal;
- or
- a mutation in at least one native HEPN domain;
- or
- a subcellular localization signal and a mutation in at least one native HEPN domain.
5 more elements
Dependencies are inferred from the claim text.