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US 11,702,465 B1Granted
Synthetic anti-plague antibodies
AssigneeTriad National Security, LLC
InventorsAntonietta Maria Lillo, Nileena Velappan, Armand Earl Ko Dichosa, Stosh Anthony Kozimor, Laura Margaret Lilley
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Abstract
Monoclonal antibodies that specifically bind the F1 antigen of Yersinia pestis with high affinity are described. Use of the monoclonal antibodies for the detection of Y. pestis infection and the diagnosis of plague are also described. Immunoconjugates of the monoclonal antibodies and a radionuclide can also be used for the treatment of a Y. pestis infection.
Claims22
A monoclonal antibody that specifically binds Yersinia pestis F1 antigen, comprising a variable light (VL) domain and a variable heavy (VH) domain, wherein:
- the VL domain comprises the complementarity determining region 1 (CDR1), CDR2 and CDR3 sequences of SEQ ID NO:
- 1 and the VH domain comprises the CDR1, CDR2 and CDR3 sequences of SEQ ID NO:
- 2;
- or
- the VL domain comprises the CDR1, CDR2 and CDR3 sequences of SEQ ID NO:
- 3 and the VH domain comprises the CDR1, CDR2 and CDR3 sequences of SEQ ID NO:
- 4.
4 more elements
Dependencies are inferred from the claim text.