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US 11,702,443 B2Granted
Therapeutic agents and methods
AssigneePop Test Oncology LLC
InventorsRandice Lisa Altschul, Neil David Theise, Andreas J. Kesel, Myron Rapkin, Rebecca O'Brien, Anthony R. Arment
Life of this patent
Estimating the term…
Abstract
The invention provides glucocorticoid receptor antagonists for treatment of infection, neoplasia, and fatty liver disease.
Claims9
A compound selected from the group consisting of:
- TPR-1, or pharmaceutically acceptable salts thereof;
- KM-1, or pharmaceutically acceptable salts thereof;
- TCY-1, or pharmaceutically acceptable salts thereof;
- PT155, or pharmaceutically acceptable salts thereof;
- PT157, or pharmaceutically acceptable salts thereof;
- PT158, or pharmaceutically acceptable salts thereof;
- PT159, or pharmaceutically acceptable salts thereof;
- PT160, or pharmaceutically acceptable salts thereof;
- PT162, or pharmaceutically acceptable salts thereof;
- PT163, or pharmaceutically acceptable salts thereof;
- PT164, or pharmaceutically acceptable salts thereof;
- PT165, or pharmaceutically acceptable salts thereof;
- PT166, or pharmaceutically acceptable salts thereof;
- PT167, or pharmaceutically acceptable salts thereof,
- and combinations thereof.
12 more elements
A pharmaceutical composition comprising a therapeutically effective amount of at least one active agent, wherein the active agent is selected from the group consisting of:
- TPR-1, TCY-1, PT150, PT155, PT157, PT158, PT159, PT160, PT162, PT163, PT164, PT165, PT166, PT167, combinations thereof, and pharmaceutically acceptable salts thereof;
- and
- at least one pharmaceutically acceptable excipient.
A method for treating neoplasia in a patient in need of such treatment, comprising:
- administering to said patient a therapeutically effective amount of at least one neoplasia-treating agent selected from the group consisting of TPR-1, TCY-1, PT150, PT155, PT157, PT158, PT159, PT160, PT162, PT163, PT164, PT165, PT166, PT167, combinations thereof, and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.