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US 11,701,650 B2Granted
Pipette tip containing one or more barriers
OwnerSergey Smulevitchinventor
Life of this patent
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Abstract
A pipette tip according to certain embodiments includes a proximal end, a distal end, and a reagent chamber. The proximal end is dimensioned to fit on an end of a pipettor, and includes a proximal end opening. The distal end includes a distal end opening. The reagent chamber has a reagent composition disposed therein. The reagent chamber is defined at least in part by a proximal barrier and a distal barrier. The reagent composition is operable to pass through the distal end opening upon rupturing of the distal barrier.
Claims13
A pipette tip comprising:
- a proximal end dimensioned to fit on an end of a pipettor, the proximal end including a proximal end opening;
- a distal end including a distal end opening;
- a reagent chamber having a reagent composition disposed therein, wherein the reagent chamber is defined at least in part by a proximal barrier and a distal barrier;
- a rupture mechanism comprising a lance and a spring, wherein the lance is configured to rupture the distal barrier when moved from a first position to a second position, and wherein the spring urges the lance toward the second position;
- and
- a catch selectively retaining the lance in the first position;
- wherein the reagent composition is operable to pass through the distal end opening upon rupturing of the distal barrier;
- and
- wherein the distal barrier prevents the reagent composition from passing through the distal end opening prior to rupturing of the distal barrier.
6 more elements
A method, comprising:
- attaching a proximal end of a pipette tip to a pipettor, wherein the pipette tip comprises a reagent composition and a barrier retaining the reagent composition within the pipette tip;
- and
- rupturing the barrier, thereby causing the reagent composition to pass through a distal end of the pipette tip and into a vessel;
- wherein rupturing the barrier comprises actuating the pipettor;
- and
- wherein the pipette tip further comprises a movable lance, and wherein actuating the pipettor releases a catch retaining the lance in a first position, thereby enabling a spring to cause movement of the lance to a second position such that the lance pierces the barrier.
3 more elements
A method, comprising:
- attaching a proximal end of a pipette tip to a pipettor, wherein the pipette tip comprises a reagent composition and a barrier retaining the reagent composition within the pipette tip;
- and rupturing the barrier, thereby causing the reagent composition to pass through a distal end of the pipette tip and into a vessel;
- wherein rupturing the barrier comprises releasing a catch to thereby cause a spring to push a lance of the pipette tip in a proximal direction such that the lance pierces the barrier.
A pipette tip comprising:
- a proximal end dimensioned to fit on an end of a pipettor, the proximal end including a proximal end opening;
- a distal end including a distal end opening;
- and
- a reagent chamber having a reagent composition disposed therein, wherein the reagent chamber is defined at least in part by a proximal barrier and a distal barrier;
- a rupture mechanism configured to rupture the proximal barrier and the distal barrier, wherein the rupture mechanism comprises a lance and a spring urging the lance to rupture the proximal barrier and the distal barrier;
- wherein the reagent composition is operable to pass through the distal end opening upon rupturing of the proximal barrier and the distal barrier.
3 more elements
Dependencies are inferred from the claim text.