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US 11,701,369 B2Granted
Polymeric bile acid derivatives inhibit Hepatitis B and D virus and NTCP transport
AssigneeHuahui Health Ltd.
InventorsWenhui Li, Xiangbing Qi, Huan Yan, Yang Liu, Zhiqiang Wang, Bo Peng, Lei Zhang
Life of this patent
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Abstract
The invention provides for treating HBV or HDV infection or inhibiting human sodium taurocholate co-transporting polypeptide (hNTCP) with a polymeric bile acid or salt thereof, and pharmaceutical compositions comprising a polymeric bile acid or salt thereof, and a second HBV or HDV medicament.
Claims9
A compound of the following Formula, a stereoisomer, or a salt thereof:
- wherein:
- G1 is OH or
- G2 and G3 are independently OH or H, provided that they are not both OH, or G2 and G3 together with the carbon they are both attached to form
- G4 and G5 are both hydrogen,
- or when L is a bond, G4 and G5 are both OH, both hydrogen, or G4 and G5 form a bond,
- L is
- a bond,
- wherein:
- m is 1-7, X is O or NH.
6 more elements
A compound, or a salt thereof, wherein the compound is selected from:
Dependencies are inferred from the claim text.