Antibacterial compounds
AssigneeKent Innovation & Enterprise
InventorsJennifer Hiscock, Daniel Mulvihill, Gary Robinson
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Abstract
The present invention relates to certain compounds of formula (I) wherein—Ar is (Ar1) or (Ar2) and to their uses as antibacterial agents. The invention further relates to methods of treatment of bacterial infection with such compounds, optionally in combination with other antimicrobials and to compositions and pharmaceutical formulations containing such compounds. The invention additionally relates to coatings containing such compounds and to items having such coatings.
Claims18
A method of reducing the number or preventing the multiplication of live Gram-negative and/or Gram-positive bacteria on a surface comprising a step of applying to the surface a solution of a compound of formula (I):
- wherein
- Ar is
- X is O, S, or NH;
- A is such that Am− is an oxygen-containing anionic group;
- Y is such that Yn+ is an inorganic or organic cation or proton (Ft);
- G is N or CH;
- E is S, O or NH;
- R6 and R7 are independently selected for each value of q from hydrogen or a straight-chain, branched chain or cyclic or polycyclic C1 to C10 hydrocarbyl group;
- R1-R5, R8 and R9 are selected from hydrogen, —CF3, —CCl3, —NHR10, —NR210, —OR10, —OH, —NHC(O)R10, —OCOR10, —COH, —COR10, COOH, COOR10, CONH2, —CN, —SO3H NO2, —OMe, —NH2, halogen, CONHR10, —C(O)NH(CH2)SO3—, a straight-chain, branched chain or cyclic or polycyclic C1 to C10 hydrocarbyl group, a cyclic or polycyclic group comprising 1 or more heteroatoms selected from O, N and S and optionally further substituted with a straight-chain or branched chain C1-C8 hydrocarbyl group, or a nucleobase-containing group
- wherein, optionally, at least one of the pairs of groups R1/R2, R2/R3, R3/R4 and R4/R5 is such that the pair(s) form a cyclic or polycyclic moiety, optionally comprising one or more heterotatoms, fused to the benzene ring in Ar1, or the pair R8/R9 forms a cyclic or polycyclic moiety fused to the ring substituted with G and E in Ar2 wherein the cyclic or polycyclic moiety is optionally substituted with a straight-chain or branched chain C1-C8 hydrocarbyl group;
- R10 is a straight-chain, branched chain or cyclic or polycyclic C1 to C10 hydrocarbyl group;
- q is an integer from 1-10;
- and
- m and n are each independently an integer from 1-3.
A method of treatment of a bacterial infection, comprising administering to an animal an effective amount of a composition comprising at least one compound of formula (I):
- wherein
- Ar is
- X is O, S, or NH;
- A is such that Am− is an oxygen-containing anionic group;
- Y is such that Yn+ is an inorganic or organic cation or proton (H+);
- G is N or CH;
- E is S, O or NH;
- R6 and R7 are independently selected for each value of q from hydrogen or a straight-chain, branched chain or cyclic or polycyclic C1 to C10 hydrocarbyl group;
- R1-R5, R8 and R9 are selected from hydrogen, —CF3, —CCl3, —NHR10, —NR210, —OR10, —OH, —NHC(O)R10, —OCOR10, —COH, —COR10, COOH, COOR10, CONH2, —CN, —SO3H NO2, —OMe, —NH2, halogen, CONHR10, —C(O)NH(CH2)SO3—, a straight-chain, branched chain or cyclic or polycyclic C1 to C10 hydrocarbyl group, a cyclic or polycyclic group comprising 1 or more heteroatoms selected from O, N and S and optionally further substituted with a straight-chain or branched chain C1-C8 hydrocarbyl group, or a nucleobase-containing group
- wherein, optionally, at least one of the pairs of groups R1/R2, R2/R3, R3/R4 and R4/R5 is such that the pair(s) form a cyclic or polycyclic moiety, optionally comprising one or more heterotatoms, fused to the benzene ring in Ar1, or the pair R8/R9 forms a cyclic or polycyclic moiety fused to the ring substituted with G and E in Ar2 wherein the cyclic or polycyclic moiety is optionally substituted with a straight-chain or branched chain C1-C8 hydrocarbyl group;
- R10 is a straight-chain, branched chain or cyclic or polycyclic C1 to C10 hydrocarbyl group;
- q is an integer from 1-10;
- and
- m and n are each independently an integer from 1-3.
The method as claimed in 7, wherein the Gram-positive bacteria are staphylococci, and/or the Gram-negative bacteria are Enterobacteriaceae.
Dependencies are inferred from the claim text.