Near infrared fluorescent biosensors for steroid hormones
AssigneeMassachusetts Institute of Technology
InventorsMichael Strano, Michael Lee, Naveed Bakh, Song Wang
Life of this patent
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Abstract
Corona Phase Molecular Recognition (CoPhMoRe) utilizing a template heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte can be used for macromolecular analytes, including proteins.
Claims23
A composition, comprising:
- a complex, wherein the complex includes:
- a nanostructure;
- and
- a polymer, the polymer adsorbed on the nanostructure and the polymer being free from selective binding to an analyte in the absence of being adsorbed on the nanostructure, wherein the polymer is a heteropolymer including a hydrophobic region and a hydrophilic region and the polymer includes a template moiety;
- and
- a selective binding site associated with the complex, the selectivity of the selective binding site being dependent on the template moiety.
A method of making a composition including templating a composition that selective binds an analyte, wherein templating includes contacting a nanostructure, and a polymer, the polymer adsorbed on the nanostructure and the polymer being free from selective binding to an analyte in the absence of being adsorbed on the nanostructure, wherein the polymer is a heteropolymer including a hydrophobic region and a hydrophilic region and the polymer includes a template moiety.
Dependencies are inferred from the claim text.