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US 11,698,334 B2Granted
Flow cytometer with optical equalization
AssigneeBecton, Dickinson and Company
InventorsEric D. Diebold, Keegan Owsley, Matthew Bahr
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Abstract
Aspects of the present disclosure include methods for producing an output laser beam having two or more angularly deflected laser beams (e.g., for irradiating a sample in a flow stream) with a predetermined intensity profile. Systems for practicing the subject methods having a laser, an acousto-optic device, a radiofrequency generator and a controller for adjusting the amplitude of the radiofrequency drive signals to produce an output laser beam of angularly deflected laser beams with a predetermined intensity profile are also described.
Claims22
A method comprising:
- applying a first radiofrequency drive signal and a second radiofrequency drive signal to an acousto-optic device;
- irradiating the acousto-optic device with a laser to generate a plurality of independently-controlled angularly deflected laser beams that collectively form an output excitation beam;
- splitting the output excitation beam into a first plurality of angularly deflected laser beams and a second plurality of angularly deflected laser beams;
- propagating the first plurality of angularly deflected laser beams along a first optical path;
- and
- propagating the second plurality of angularly deflected laser beams along a second optical path.
3 more elements
A system comprising:
- a laser;
- an acousto-optic device;
- a radiofrequency generator configured to apply a first radiofrequency drive signal and a second radiofrequency drive signal to the acousto-optic device to generate an output excitation beam comprising a plurality of independently-controlled angularly deflected laser beams;
- and
- an optical component configured to split the output excitation beam into a first plurality of angularly deflected laser beams and a second plurality of angularly deflected laser beams and to propagate the first plurality of angularly deflected laser beams along a first optical path and to propagate the second plurality of angularly deflected laser beams along a second optical path.
2 more elements
Dependencies are inferred from the claim text.