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US 11,697,852 B2Granted
Systems and methods for determining a treatment course of action
AssigneeThe Regents of the University of Michigan
InventorsArul M. Chinnaiyan, Dan Robinson, Yi-Mi Wu
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Abstract
The present disclosure relates to methods of determining a treatment course of action. In particular, the present disclosure relates to mutations in the gene encoding estrogen receptor and their association with responsiveness to estrogen therapies for cancer.
Claims7
A method of detecting the presence of a variant estrogen receptor (ESR1) gene, comprising:
- a) i) assaying a sample for the presence of a p.Leu536Gln variation in the ESR1 gene, ii) and further assaying said sample for p.Tyr537Ser and/or p.Tyr537Asn variations, wherein said assaying comprises the use of nucleic acid molecules that detect the presence of said variations;
- and
- b) identifying the presence of a p.Leu536Gln variation in said sample.
Dependencies are inferred from the claim text.